Prof. BEWAJI, Clement Olatubosun B. Sc., M.Phil., PhD. (Ibadan)

Department of Biochemistry

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Research interest: Membrane Biochemistry and Bioinformatics

On-going research

  1. Proteomic studies on Plasmodium falciparum, Mycobacterium tuberculosis, HIV.
  2. Interaction of antimalarials with membrane bound Ca2+ ATPase.
  3. Nutritional intervention in Tuberculosis Treatment (Collaborative research)

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RESEARCH WORK DONE AND PUBLICATIONS:

Unpublished

 

  1. Bewaji, C. O. (1983) A comparative study of the structures of red cell membranes and the calcium-pumping adenosine triphosphatase in some mammalian species. Phil. Dissertation, University of Ibadan, Nigeria. 232 pp.
  2. Bewaji, C. O. (1985) The isolation and characterization of porcine erythrocyte Ca2+-adenosine triphosphatase.  D. Thesis, University of Ibadan, Nigeria. 202 pp.

 

Published

  1. Bababunmi, E. A.; Bolaji, O. M.; Bewaji, C. O. and Olorunsogo, O. O. (1983) Calmodulin in the bloodstream forms of Trypanosoma brucei.  Fed. Proc. 42, 1087 (Abstract).
  2. Bewaji, C. O. and Bababunmi, E. A. (1987) The calcium-pumping adenosine triphosphatase of porcine erythrocyte membranes. In: Proceedings of the VIIth International Washington Spring Symposium on Cell Calcium Metabolism, Washington, D.C., May 19 – 22, 1987.  Abstract 115.
  3. Bewaji, C. O.; Olorunsogo, O. O. and Bababunmi, E. A. (1985) Sickle-cell membrane-bound (Ca2+ + Mg2+)-ATPase: activation by 3,4-dihydro-2,2-dimethyl-2H-1-benzopyran-6-butyric acid, a novel antisickling agent.  Cell Calcium 6, 237 – 244. http://www.ncbi.nlm.nih.gov/pubmed/3160469 .
  4. Bewaji, C. O.; Olorunsogo, O. O. and Bababunmi, E. A. (1985) Comparison of the membrane-bound (Ca2+ + Mg2+)-ATPase in erythrocyte ghosts from some mammalian species.  Comp. Biochem. Physiol. 82B, 117 – 122. http://www.ncbi.nlm.nih.gov/pubmed/2932279 .
  5. Ogunleye, A. J.; Oloyede, O. B.; Bewaji, C. O. and Odutuga, A. A. (1986) Comparative effects of essential fatty acids and methionine deficiencies on the cerebrum and cerebellum of the rat.  Nig. J. Pur. Appl. Sci. 1, 49 – 61.
  6. Bewaji, C. O. and Bababunmi, E. A. (1987)  Further characterization of the (Ca2+ + Mg2+)-ATPase from porcine erythrocytes.  Int. J. Biochem. 19, 721 – 724. http://www.ncbi.nlm.nih.gov/pubmed/2957253 .
  7. Bewaji, C. O. and Bababunmi, E. A. (1987) Abundance of the Ca2+-pumping ATPase in pig erythrocyte membranes.  Biochem. J. 248, 297 – 299. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1148536/pdf/biochemj00243-0282.pdf
  8. Bewaji, C. O. and Odutuga, A. A. (1987) Interaction of some local anaesthetic and antisickling drugs with calcium-carrier proteins in biomembranes.  Nig. J. Pur. Appl. Sci. 2, 6 – 13.
  9. Bewaji, C. O. and Bababunmi, E. A. (1989)  Studies on the activation of porcine erythrocyte calcium-pumping ATPase by limited proteolysis.  Biosci. Res. Commun. 1, 9 – 18. (Published by Nigerian Society for Experimental Biology, http://www.niseb.org ).
  10. Ogunleye, A. J. and Bewaji, C. O. (1990)  Monovalent cation and water contents of red blood cells in some diseased states.  Med. Sci. Res. 18, 631 – 632.
  11. Bababunmi, E. A.; Olorunsogo, O. O. and Bewaji, C. O. (1990)  Comparative properties of erythrocyte calcium-transporting enzyme in different mammalian species. Wld. Rev. Nutr. Diet. 64, 109 – 138. http://www.ncbi.nlm.nih.gov/pubmed/1851353 .
  12. Bewaji, C. O. (1991) Immunological cross-reactivity between Ca2+-ATPases from human and porcine erythrocytes.  Biokemistri 1, 9 – 16. (Published by Nigerian Society for Experimental Biology, http://www.niseb.org ).
  13. Bewaji, C. O.; Oyedotun, K. S. and Malomo, S. O. (1991)  Studies on adenosine triphosphatase activities in homogenates of rat brain and liver.  Biokemistri 1, 71 – 82. (Published by Nigerian Society for Experimental Biology, http://www.niseb.org ).
  14. Bewaji, C. O. and Tebit, H. N. (1991)  Interaction of suramin and difluoromethyl ornithine with adenosine triphosphatases in some rat tissues.  Biokemistri 1, 109 – 116. (Published by Nigerian Society for Experimental Biology, http://www.niseb.org ).
  15. Bewaji, C. O.; Ojo, C. I.; Malomo, S. O. and Odutuga, A. A. (1991)  Effects of some antimalarial drugs on adenosine triphosphatase activities in rat liver and brain. Bioscience Res. Commun. 3, 243 – 251. (Published by Nigerian Society for Experimental Biology, http://www.niseb.org).
  16. Bewaji, C. O. (1991) Biochemistry of sickle cell disease and related haemoglobinopathies.  Biokemistri 1, 117 – 125. (Published by Nigerian Society for Experimental Biology, http://www.niseb.org ).
  17. Bewaji, C. O. (1993) Studies on vanadium interactions with the membrane-bound calcium-pumping ATPase from porcine erythrocytes.  Nig. J. Biochem.  8, 18 – 22. (Published by Nigerian Society for Biochemistry and Molecular Biology).
  18. Bewaji, C. O.; Oyedotun, K. S. and Malomo, S. O. (1993)  Further characterization of adenosine triphosphatases in homogenates of rat brain and liver: Effects of temperature, pH and vanadate.  Biokemistri 3, 115 – 122. (Published by Nigerian Society for Experimental Biology, http://www.niseb.org ).
  19. Bababunmi, E. A.; Olorunsogo, O. O. and Bewaji, C. O. (1994)  Pathological and chemical effectors of the erythrocyte calcium pumping protein: A review.  Trop. J. Hlth. Sci. 1, 33 – 47. (Published by College of Health Sciences, University of Ilorin, Nigeria, http://www.unilorin.edu.ng ).
  20. Bewaji, C. O.; Akanji, M. A.; Oloyede, O. B. and Odutuga, A. A. (1994)  Studies on ATPase activities in Onchocerca armillataBiokemistri 4, 45 – 49. (Published by Nigerian Society for Experimental Biology, http://www.niseb.org ).
  21. Bewaji, C. O. and Dawson, A. P. (1995) Thapsigargin protects human erythrocyte Ca2+-ATPase from proteolysis.  Cell Calcium 17, 14 – 20. http://www.ncbi.nlm.nih.gov/pubmed/7553777 .
  22. Bewaji, C. O. (1995) Calcium pump isoforms of the cell surface and intracellular membranes.  Biokemistri 5(2), 75 – 86. (Published by Nigerian Society for Experimental Biology, http://www.niseb.org ).
  23. Bewaji, C. O. (1995) Ionic requirements for inositol trisphosphate- and thapsigargin-induced Ca2+ release from rat liver endoplasmic reticulum.  Nig. J. Biochem. Mol. Biol. 10, 1 – 6. (Published by Nigerian Society for Biochemistry and Molecular Biology).
  24. Bewaji, C. O. (1996) Inhibitor sensitivities of the Ca2+-ATPase from skeletal muscle sarcoplasmic reticulum after proteolysis with trypsin.  Biokemistri 6(2), 52 – 58. (Published by Nigerian Society for Experimental Biology, http://www.niseb.org ).
  25. Bewaji, C. O. (1996) Comparison of the effects of thapsigargin, 2,5-di-(tert-butyl)-1,4-hydroquinone and cyclopiazonic acid on calcium release from rat liver endoplasmic reticulum.  Nig. J. Biochem. Mol. Biol.  11, 27 – 30. (Published by Nigerian Society for Biochemistry and Molecular Biology).
  26. Bewaji, C. O., Rich, G. and Dawson, A. P. (1998)  Inhibitor sensitivities of the Ca2+-ATPase and Ca2+-dependent p-nitrophenyl phosphatase activities of skeletal muscle sarcoplasmic reticulum.  Biokemistri 8, 1 – 13. (Published by Nigerian Society for Experimental Biology, http://www.niseb.org ).
  27. Bewaji, C. O. (1999) Identification of drug target sites and vaccine candidates in Plasmodium falciparum using functional genomics.  Trop. J. Hlth. Sci. 6, 1 – 6. (Published by College of Health Sciences, University of Ilorin, Nigeria, http://www.unilorin.edu.ng ).
  28. Bewaji, C. O. (2000) Darwin’s Genesis: An update on the human genome project.  African Scientist 1(1), 11 – 16. (Published by Nigerian Society for Experimental Biology, http://www.niseb.org ).
  29. Bewaji, C. O. (2000) Another look at genetic engineering. African Scientist 1(1), 17 – 22.
  30. Bolaji, O. M.; Bewaji, C. O.; Oduola, A. M. J. and Bababunmi, E. A. (2000)  Expression of calcium-binding proteins (Ca2+-ATPase and translationally controlled tumor protein) in chloroquine resistant Plasmodium falciparum: A possible role of the proteins in apoptosis of the parasite.  Biokemistri 10, 111 – 121. (Published by Nigerian Society for Experimental Biology, http://www.niseb.org ).
  31. Bewaji, C. O. (2000) Bioinformatics: An emerging new academic discipline.  African Scientist 1(2), 121 – 125. (Published by Nigerian Society for Experimental Biology, http://www.niseb.org ).
  32. Bewaji, C. O. (2000) Rolling Back Malaria: The role of Bioinformatics. African Scientist 1(2), 127 – 141. (Published by Nigerian Society for Experimental Biology, http://www.niseb.org ).
  33. Bewaji, C. O. (2000) Digital representation of the amino acid sequence of proteins and comparison of sequences using the Microsoft Excel software.  African Scientist 1(3), 197 – 206.
  34. Bewaji, C. O. (2000) A bioinformatics approach to the study of the Acquired Immune Deficiency Syndrome (AIDS).  African Scientist 1(3), 207 – 214. (Published by Nigerian Society for Experimental Biology, http://www.niseb.org ).
  35. Bewaji, C. O. and Bababunmi, E. A. (2001) Mycotoxins in Nigerian Foodstuffs. NISEB Journal 1(4), 361 – 365. http://www.unilorin.edu.ng/publications/bewaji/nisebj141200018.pdf .
  36. Bababunmi, E. A. and Bewaji, C. O. (2002) Oxidative stress and antioxidant therapy in wasting conditions associated with malnutrition, HIV/AIDS, tuberculosis and malaria.  Biokemistri 12(3), 135 – 139. (Published by Nigerian Society for Experimental Biology, http://www.niseb.org).
  37. Bewaji, C. O. (2002) Bioinformatics, Genomics and Proteomics: Scientific Challenge of the Twenty-First Century. African Scientist 3(4), 101 – 104.
  38. Bewaji, C. O. (2002) Sickle-cell and malaria.  African Scientist 3(2), 31 – 34.
  39. Bewaji, C. O. (2003) The sickle-cell membrane: Tip of the iceberg. Sixty-fourth Inaugural Lecture delivered on February 27, 2003, at the University of Ilorin, Nigeria. Published by the Library and Publications Committee, University of Ilorin, Nigeria. 38pp.
  40. Bewaji, C. O. (2003) Data mining in novel genomes. African Scientist 4(1), 43 – 49. https://unilorin.edu.ng/publications/bewaji/afs4107.pdf
  41. Bewaji, C. O. and Bababunmi, E. A. (2004) Gene arrangements in human chromosomes: Recent findings from the Human Genome Project.  African Scientist  5(4), 203 – 210. (Published by Nigerian Society for Experimental Biology, http://www.niseb.org ).
  42. Bewaji, C. O. and Bababunmi, E. A. (2006) Comparison of the proteomes of three Plasmodium species: Plasmodium falciparum, Plasmodium vivax and Plasmodium yoelii. Int. J. Biomed. Hlth. Sci. 2(2), 115 – 124. (Published by African Studies on Population and Health, http://www.asopah.org ).
  43. Afolabi, O. M.; Saliu, O. R. and Bewaji, C. O. (2008) A functional genomics approach towards the understanding of drug resistance in malaria. African Scientist, 9(4), 135 – 144. (Published by Nigerian Society for Experimental Biology, http://www.niseb.org ).
  44. Bewaji, C. O. and Bababunmi, E. A. (2008) Jasmonates: Mechanism of action and role in calcium homeostasis. International Journal of Biomedical and Health Sciences 4(4), 169 – 177.  http://unilorin.edu.ng/publications/bewaji/ijbhs440508078.pdf
  45. Oladele, T. O.; Bamigbola, O. M. and Bewaji, C. O. (2009) On efficiency of sequence alignment algorithms. African Scientist, 10(1), 9 – 14. http://unilorin.edu.ng/publications/bewaji/afs1010208077.pdf
  46. Yusuf, K. O. and Bewaji, C. O. and Ekanem, J. T. (2010) Biochemical evaluation of fermented wheat germ extract on Trypanosoma brucei-infected rats. Afr. J. Biomed. Res. 13, 219 – 224. (Published Ibadan Biomedical Research Group, http://www.ajbrui.net).
  47. Yusuf, K. O. and Bewaji, C. O. (2010) Effect of extracts of fermented wheat and garlic bulb on some haematological and electrolyte parameters in T. brucei-infected rats. International Journal of Applied Biological Research 2(2), 25 – 30.
  48. Bewaji, C. O. (2011) Biochemistry and Bioinformatics. Transactions of the Nigerian Society of Biochemistry and Molecular Biology, 1(1), 5 – 13. (Published by Nigerian Society of Biochemistry and Molecular Biology).
  49. Yusuf, K. O. and Bewaji, C. O. (2011) Evaluation of essential oils composition of methanolic Allium sativum extract on Trypanosoma brucei infected rats. Research in Pharmaceutical Biotechnology 3(2), 17 – 21. (Published by Academic Journals, http://www.academicjournals.org).
  50. Yusuf, K. O. and Bewaji, C. O. (2011) GC-MS of volatile components of fermented wheat germ extract. Journal of Cereals and Oilseeds 2(3), 38 – 42. (Published by Academic Journals, http://www.academicjournals.org).
  51. Oladele, T. O.; Sadiku, J. S. and Bewaji, C. O. (2011) In silico characterization of some hypothetical proteins in the proteome of Plasmodium falciparum. Centrepoint Journal, 17(2), 129 – 139. http://unilorin.edu.ng/ejournals/index.php/science/article/view/312
  52. Mejiuni, I. O. and Bewaji, C. O. (2012) Effects of some antimalaria drugs on adenosine triphosphatases in rat skeletal muscle. NISEB Journal 12(2), in press. (Published by Nigerian Society for Experimental Biology, http://www.niseb.org).
  53. Oladele, T. O.; Bewaji, C. O. and Sadiku, J. S. (2012) Drug target selection for malaria: Molecular basis for the drug discovery process.  Centrepoint Journal, 18(2), 111 – 124. http://unilorin.edu.ng/ejournals/index.php/science/article/viewFile/682/376
  54. Raji, M. O. and Bewaji, C. O. (2012) Drug resistance in malaria treatment: A review. African Scientist, 13(4), 205 – 224. (Published by Nigerian Society for Experimental Biology, http://www.niseb.org).
  55. Bewaji, C. O.; Salami, A. K. and Bababunmi, E. A. (2013) Effective combination therapies for preventing and treating highly prevalent human diseases: cancers, heart-failure, tuberculosis and malaria. International Journal of Biomedical and Health Sciences 9(3), 121 – 125.
  56. Fatumo, S. A.; Adoga, M. P.; Ojo, O. O.; Oluwagbemi, O.; Adeoye, T.; Ewejobi, T.; Adebiyi, M.; Adebiyi, E.; Bewaji, C. And Nashiru, O. (2014) Computational biology and bioinformatics in Nigeria. PLoS Computational Biology 10(4), e1003516. http://www.ncbi.nlm.nih.gov/pubmed/24763310
  57. Adeoye, A. O. and Bewaji, C. O. (2015) Therapeutic potentials of Adansonia digitata (Bombacaceae) stem bark in Plasmodium berghei-infected mice. Journal of Biological Sciences 15(2), 78 – 84. [https://www.researchgate.net/publication/281967641_Therapeutic_Potentials_of_Adansonia_digitata_Bombacaceae_Stem_Bark_in_Plasmodium_berghei-Infected_Mice].
  1. Osafo C, Raji YR, Burke D, Tayo BO, Tiffin N, Moxey-Mims MM, Rasooly RS, Kimmel PL, Ojo A, Adu D, Parekh RS; H3Africa Kidney Disease Research Network Investigators as members of The H3Africa Consortium [Adu D, Osafo C, Nyarko A, Ghansah A, Boima V, Mate-Kole M, Adabayeri V, Ekem I, Plange-Rhule J, Mengistu Y, Mc'Ligeyo S, Salako B, Amodu O, Raji YR, Ademola A, Adindu C, Olanrewaju T, Bewaji C, Arogundade F, Ajayi S, Mamven M, Ulasi I, Ijoma C, Tiffin N, Gamiedien J, Mapiye D, Cooper R, Tayo B, Gbadegesin R, Ojo A, Kretzler M, Boehnke M, Moran J, Burke D, Lyons R, Brosius FC, Clauw D, Hildebrandt F, Pollak M, Parekh R, Kopp J, Kimmel P, Winkler C, Rasooly R, Moxey-Mims M, Adeyemo A, Skorecki K, Wasser WG] Human Heredity and Health (H3) in Africa Kidney Disease Research Network: A Focus on Methods in Sub-Saharan Africa. Clin J Am Soc Nephrol. 2015 Dec 7;10(12):2279-87. doi: 10.2215/CJN.11951214. Epub 2015 Jul 2. PMID: 26138261.

http://www.ncbi.nlm.nih/gov/pubmed/26138261.